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关联公司
Algok 生物
Welcome
We're an experienced and talented group of entrepreneurs and scientists with a groundbreaking idea that we hope will be better tomorrow.
概要
| 成立日期 | 2020.09 |
|---|---|
| 企业代表 | Sung Chul Kim |
| 注册资本 | USD 2,566,667 |
| 主要产业 | 非小细胞肺癌（NSCLC）靶向抗癌药（AGK-102:抗TM4SF4单克隆抗体）백금계저항성 난소암 적용 엽산수용체알파(Folate Receptor alpha, FRα) 표적항암제 (Idetrexed(이데트렉세드) |
| 代表电话 | +1-425-598-2107 |
| 公司地址 | 320 120th Ave. NE, Suite 208 Bellevue, WA 98005, USA |
AGK-102:
Anti-TM4SF4
monoclonal antibody
| Licensed Technology |
· Invented by Korea Atomic Energy Research Institute in Korea · Algok obtained an exclusive global right for all uses of novel TM4SF4 monoclonal antibody for cancer therapeutics · Sponsored research is planned for 3 years |
|---|---|
| MoA |
· First-in-class · TM4SM4 as a novel cancer stem cell biomarker related to resistance of radiotherapy · Anti-TM4SM4 treatment suppresses tumors by down-regulation of OPN and blocking IGF1R signaling |
| Target Indications |
· NSCLC, pancreatic, liver, blood cancer expressing TM4SM4 |
| Development Stage |
· Initiation of preclinical development in 2H 2022 |
| Intellectual Properties |
· 3 PCT filed including the composition of matter of novel antibody sequences |
| Publications |
· 2 Published in OncoTarget in 2015 and 2017 |
Background
Cancer stem cell as root of tumor recurrence
CSC is characterized by self‐renewal, metastasis, apoptosis, heterogeneity, immune resistance, and radio/chemo resistance.
Mechanism of
Action
TM4SF4: a novel anti-tumor target in radio-resistant cancer cells
TM4SF4 is highly expressed in radio-resistant lung adenocarcinoma cells.
Tumorigenic activity of TM4SF4 in lung adenocarcinoma xenograft was completely suppressed by anti-TM4SF4 antibody treatment.
